Multiple Biatrial Thromboses in a Patient with End-Stage Nonobstructive Hypertrophic Cardiomyopathy

A 72-year-old patient with a history of nonobstructive hypertrophic cardiomyopathy type III and atrial fibrillation of several years’ duration presented to the emergency department with dyspnea at rest (New York Heart Association functional class IV). The patient had been using metoprolol, digoxin, furosemide, and warfarin and had a history of significant variations in the International Normalized Ratio (INR). Physical examinations revealed irregular pulse (80 bpm), pulmonary fine rales in the half lower part of both lungs, and lower extremity edema (2+). The patient was admitted for the treatment of decompensated heart failure. Transthoracic echocardiography revealed normal left ventricular end-diastolic diameter and volume and reduced left ventricular systolic function (ejection fraction = 47%, by the modified Simpsons method) with maximal wall thickness in the mid anteroseptal portion (26 mm) and a large mass in the left atrium. Next, transesophageal echocardiography was done and it showed 1 fixed large thrombosis (50 × 40 mm) attached to the roof of the left atrium and another thrombosis with an echo-lucent center attached to the roof of the right atrium. Additionally, the left atrial appendage was obliterated by clot (Figure 1 and Figure 2). There was a significant smoky pattern in both atriums. The patient was dis-